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KMID : 0043320050280111282
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Archives of Pharmacal Research
2005 Volume.28 No. 11 p.1282 ~ p.1286
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Immunomodulatory Function of Murine NK Cell Activity by Alginate
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Son Eun-Wha
Yang Kwang-Hee
Rhee Dong-Kwon
Pyo Suhkneung
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Abstract
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The in vivo immunomodulatory function of the activity of murine natural killer (NK) cells induced by high mannuronic acid-containing alginate (HMA) was examined. HMA was injected i.p at doses of 25 and 100 mg/kg. The NK activity was 3 times higher with 100 mg/kg HMA than the baseline. In addition, in vitro studies of splenocytes cultured with HMA for 20 h showed a significant increase in NK activity at E:T ratio of 100: 1; a 160 and 210 increase at 10 and 100 g/mL, respectively. There was a six fold increase in interferon- production in a postculture of splenocytes with 100 g/mL HMA. HMA had no suppressive effects on the lymphocyte function in the presence or absence of mitogens. This suggests that HMA is useful in cancer immunotherapy.
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KEYWORD
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Alginate, NK cell, Cytotoxicity
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